SOUZA, R. A.; VOLTOLINI, T. V.; ARAÚJO, G. G. L. de; MANERA, D. B.; BELM, K. V. J.; PEREIRA, L. G. R.; SANTOS, E. F. dos.
Fonte: In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 46., 2009, Maringá. Inovação científica e tecnológica em zootecnia: anais dos resumos. Maringa: SBZ: UEM, 2009.Publicador: In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 46., 2009, Maringá. Inovação científica e tecnológica em zootecnia: anais dos resumos. Maringa: SBZ: UEM, 2009.
Tipo: Artigo em anais de congresso (ALICE)Formato: 1 CD-ROM.
Thoracic aortic aneurysms and dissections (TAAD) cause significant morbidity and mortality, but the genetic origins of TAAD remain largely unknown. In a genome-wide analysis of 418 sporadic TAAD cases, we identified 47 copy number variant (CNV) regions that were enriched in or unique to TAAD patients compared to population controls. Gene ontology, expression profiling, and network analysis showed that genes within TAAD CNVs regulate smooth muscle cell adhesion or contractility and interact with the smooth muscle-specific isoforms of α-actin and β-myosin, which are known to cause familial TAAD when altered. Enrichment of these gene functions in rare CNVs was replicated in independent cohorts with sporadic TAAD (STAAD, n = 387) and inherited TAAD (FTAAD, n = 88). The overall prevalence of rare CNVs (23%) was significantly increased in FTAAD compared with STAAD patients (Fisher's exact test, p = 0.03). Our findings suggest that rare CNVs disrupting smooth muscle adhesion or contraction contribute to both sporadic and familial disease.
The different electron distributions in the hard and soft spectral states (HS
and SS) of BH binaries could be caused by kinetic processes and changing
because of varying physical conditions in the corona. In presence of a magnetic
field in the corona, the electron distribution can appear thermal, even when
acceleration mechanisms would produce non thermal distributions. This is due to
fast and efficient thermalization through synchrotron self-absorption. We have
analyzed data from 6 years of observations of Cygnus X-1 with the INTEGRAL
observatory and produced 12 high-quality, stacked broad-band hard X-ray spectra
representative of the whole range of spectral shapes observed. We then fit
these spectra with hybrid thermal/non-thermal Comptonization models and study
the evolution of the physical parameters of the accretion flow across the
spectral transition. In particular, we use the BELM model to constrain the
magnetic field in the corona through its effects on the coronal emission.
Indeed, the hot electrons of the X-ray corona produce soft (optical-UV)
synchrotron radiation which is then Comptonized and may affect the temperature
of the electrons through Compton cooling. We find that in the SS, the emission
is dominated by Comptonization of the disc photons and the magnetic field is at
most of the order of 1E+06 G. In the hard states...
We present an extension of the BELM code (Belmont et al 2008) to investigate
the microphysics of particle acceleration in black holes accretion disc corona.
The updated version of the code accounts for the dynamics of resonant slab
waves as well as their interaction with both leptons or protons. It is found
that the proton temperature is an important regulating effect of the stochastic
particle acceleration process in accretion disk corona. We present a
preliminary fit of the high soft spectral state of Cygnus X-1.; Comment: Proceedings of "An INTEGRAL view of the high-energy sky (the first 10
years)" the 9th INTEGRAL Workshop, October 15-19, 2012, Paris, France, in
Proceedings of Science (INTEGRAL 2012), Eds. A. Goldwurm, F. Lebrun and C.
Winkler, (http://pos.sissa.it/cgi-bin/reader/conf.cgi?confid=176), id=176
We study the high-energy emission of the Galactic black hole candidate GX
339-4 using INTEGRAL/SPI and simultaneous RXTE/PCA data. By the end of January
2007, when it reached its peak luminosity in hard X-rays, the source was in a
bright hard state. The SPI data from this period show a good signal to noise
ratio, allowing a detailed study of the spectral energy distribution up to
several hundred keV. As a main result, we report on the detection of a variable
hard spectral feature (>150 keV) which represents a significant excess with
respect to the cutoff power law shape of the spectrum. The SPI data suggest
that the intensity of this feature is positively correlated with the 25 - 50
keV luminosity of the source and the associated variability time scale is
shorter than 7 hours. The simultaneous PCA data, however, show no significant
change in the spectral shape, indicating that the source is not undergoing a
canonical state transition. We analyzed the broad band spectra in the lights of
several physical models, assuming different heating mechanisms and properties
of the Comptonizing plasma. For the first time, we performed quantitative model
fitting with the new versatile Comptonization code BELM, accounting
self-consistently for the presence of a magnetic field. We show that a
magnetized medium subject to pure non-thermal electron acceleration provides a
framework for a physically consistent interpretation of the observed 4 - 500
keV emission. Moreover...