Página 15 dos resultados de 45945 itens digitais encontrados em 0.038 segundos

‣ Multi-drug Resistance Protein 4 (MRP4)-mediated Regulation of Fibroblast Cell Migration Reflects a Dichotomous Role of Intracellular Cyclic Nucleotides*

Sinha, Chandrima; Ren, Aixia; Arora, Kavisha; Moon, Chang-Suk; Yarlagadda, Sunitha; Zhang, Weiqiang; Cheepala, Satish B.; Schuetz, John D.; Naren, Anjaparavanda P.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: MRP4 is an endogenous transporter of cyclic nucleotides that can regulate cell migration. The role of MRP4 in fibroblast migration is unknown.

‣ Signaling of the ITK (Interleukin 2-inducible T Cell Kinase)-SYK (Spleen Tyrosine Kinase) Fusion Kinase Is Dependent on Adapter SLP-76 and on the Adapter Function of the Kinases SYK and ZAP70*

Hussain, Alamdar; Mohammad, Dara K.; Gustafsson, Manuela O.; Uslu, Merve; Hamasy, Abdulrahman; Nore, Beston F.; Mohamed, Abdalla J.; Smith, C. I. Edvard
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: ITK-SYK is an oncogenic fusion protein in patients with peripheral T cell lymphomas carrying a unique translocation.

‣ p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress*

Thomas, Sally E.; Malzer, Elke; Ordóñez, Adriana; Dalton, Lucy E.; van ′t Wout, Emily F. A.; Liniker, Elizabeth; Crowther, Damian C.; Lomas, David A.; Marciniak, Stefan J.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: ER stress impairs progression through G1 and G2 phases of the cell cycle.

‣ Hypoglycemia Reduces Vascular Endothelial Growth Factor A Production by Pancreatic Beta Cells as a Regulator of Beta Cell Mass*

Xiao, Xiangwei; Guo, Ping; Chen, Zean; El-Gohary, Yousef; Wiersch, John; Gaffar, Iljana; Prasadan, Krishna; Shiota, Chiyo; Gittes, George K.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Beta cell VEGF-A is critical for islet vascularization and Insulin secretion.

‣ Soluble Melanoma Cell Adhesion Molecule (sMCAM/sCD146) Promotes Angiogenic Effects on Endothelial Progenitor Cells through Angiomotin*

Stalin, Jimmy; Harhouri, Karim; Hubert, Lucas; Subrini, Caroline; Lafitte, Daniel; Lissitzky, Jean-Claude; Elganfoud, Nadia; Robert, Stéphane; Foucault-Bertaud, Alexandrine; Kaspi, Elise; Sabatier, Florence; Aurrand-Lions, Michel; Bardin, Nathalie; Holmg
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Soluble melanoma cell adhesion molecule (sMCAM/sCD146) promotes angiogenic effects on endothelial progenitor cells (EPC).

‣ Class IIa Histone Deacetylases and Myocyte Enhancer Factor 2 Proteins Regulate the Mesenchymal-to-Epithelial Transition of Somatic Cell Reprogramming*

Zhuang, Qiang; Qing, Xiaobing; Ying, Yue; Wu, Haitao; Benda, Christina; Lin, Jiao; Huang, Zhijian; Liu, Longqi; Xu, Yan; Bao, Xichen; Qin, Baoming; Pei, Duanqing; Esteban, Miguel A.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Somatic cell reprogramming is an inefficient process because of the existence of roadblocks.

‣ Annexin A2 Regulates β1 Integrin Internalization and Intestinal Epithelial Cell Migration*

Rankin, Carl R.; Hilgarth, Roland S.; Leoni, Giovanna; Kwon, Mike; Den Beste, Kyle A.; Parkos, Charles A.; Nusrat, Asma
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Intestinal epithelial wound closure requires dynamic regulation/turnover of cell-matrix adhesions.

‣ The Intermediate Conductance Calcium-activated Potassium Channel KCa3.1 Regulates Vascular Smooth Muscle Cell Proliferation via Controlling Calcium-dependent Signaling*

Bi, Dan; Toyama, Kazuyoshi; Lemaître, Vincent; Takai, Jun; Fan, Fan; Jenkins, David P.; Wulff, Heike; Gutterman, David D.; Park, Frank; Miura, Hiroto
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: The mechanism by which KCa3.1 regulates cell proliferation remains elusive.

‣ Phosphorylation of Minichromosome Maintenance Protein 7 (MCM7) by Cyclin/Cyclin-dependent Kinase Affects Its Function in Cell Cycle Regulation*

Wei, Qian; Li, Junhui; Liu, Ting; Tong, Xiaomei; Ye, Xin
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Cyclin/CDKs play an important role in cell cycle regulation.

‣ The Src Homology 3 Domain-containing Guanine Nucleotide Exchange Factor Is Overexpressed in High-grade Gliomas and Promotes Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Fibroblast Growth Factor-inducible 14-induced Cell Migration and Invasion via Tumor Necrosis Factor Receptor-associated Factor 2*

Fortin Ensign, Shannon P.; Mathews, Ian T.; Eschbacher, Jennifer M.; Loftus, Joseph C.; Symons, Marc H.; Tran, Nhan L.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Glioblastoma is characterized by heightened cell invasion and therapeutic resistance.

‣ Cell Cycle-dependent Subcellular Translocation of the Human DNA Licensing Inhibitor Geminin*

Dimaki, Maria; Xouri, Georgia; Symeonidou, Ioanna-Eleni; Sirinian, Chaido; Nishitani, Hideo; Taraviras, Stavros; Lygerou, Zoi
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: The licensing inhibitor geminin must be regulated to ensure once per cell cycle replication.

‣ Planar Cell Polarity Pathway Regulates Nephrin Endocytosis in Developing Podocytes

Babayeva, Sima; Rocque, Brittany; Aoudjit, Lamine; Zilber, Yulia; Li, Jane; Baldwin, Cindy; Kawachi, Hiroshi; Takano, Tomoko; Torban, Elena
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: The PCP pathway controls many cell processes during development.

‣ Inhibition of Protein Kinase C Signaling Maintains Rat Embryonic Stem Cell Pluripotency*

Rajendran, Ganeshkumar; Dutta, Debasree; Hong, James; Paul, Arindam; Saha, Biswarup; Mahato, Biraj; Ray, Soma; Home, Pratik; Ganguly, Avishek; Weiss, Mark L.; Paul, Soumen
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Signaling mechanisms regulating rat embryonic stem cell (rESC) pluripotency are understood poorly.

‣ Identification of Cargo Proteins Specific for Importin-β with Importin-α Applying a Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based in Vitro Transport System*

Kimura, Makoto; Okumura, Nobuaki; Kose, Shingo; Takao, Toshifumi; Imamoto, Naoko
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: A limited number of cargoes specific for importin-β family nucleocytoplasmic transport carriers have been reported. We have developed a stable isotope labeling by amino acids in cell culture (SILAC)-based transport method to identify specific cargo.

‣ Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming*

Hu, Wenxiang; Zhao, Jian; Pei, Gang
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: MiR-302 regulates pluripotency genes and helps somatic cell reprogramming.

‣ Cyclin D1 Promotes Cell Cycle Progression through Enhancing NDR1/2 Kinase Activity Independent of Cyclin-dependent Kinase 4*

Du, Zhaoyang; Tong, Xiaomei; Ye, Xin
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Cyclin D1/Cdk4 and NDR1/2 are critical kinases in cell cycle regulation.

‣ ASB2α, an E3 Ubiquitin Ligase Specificity Subunit, Regulates Cell Spreading and Triggers Proteasomal Degradation of Filamins by Targeting the Filamin Calponin Homology 1 Domain*

Razinia, Ziba; Baldassarre, Massimiliano; Cantelli, Gaia; Calderwood, David A.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: The E3 ubiquitin ligase ASB2α triggers proteasomal degradation of filamins and regulates cell spreading and differentiation.

‣ Atypical Protein Kinase Cλ Is Critical for Growth Factor Receptor-induced Dorsal Ruffle Turnover and Cell Migration*

Xing, Bowen; Wang, Limin; Guo, Dagang; Huang, Jianyun; Espenel, Cedric; Kreitzer, Geri; Zhang, J. Jillian; Guo, Lin; Huang, Xin-Yun
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Growth factors induce actin cytoskeletal reorganization and cell migration in fibroblast cells.

‣ Activated Cdc42-associated Kinase 1 (Ack1) Is Required for Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Receptor Recruitment to Lipid Rafts and Induction of Cell Death*

Linderoth, Emma; Pilia, Giulia; Mahajan, Nupam P.; Ferby, Ingvar
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Activated TRAIL receptors accumulate in lipid raft membrane domains to trigger cell death.

‣ Phosphorylation and mRNA Splicing of Collapsin Response Mediator Protein-2 Determine Inhibition of Rho-associated Protein Kinase (ROCK) II Function in Carcinoma Cell Migration and Invasion*

Morgan-Fisher, Marie; Couchman, John R.; Yoneda, Atsuko
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Kinase activity of ROCK II, an important regulator of cell migration, is controlled by its endogenous inhibitor CRMP-2.