Página 16 dos resultados de 45945 itens digitais encontrados em 0.038 segundos

‣ Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation*

Yun, Bogeon; Lee, HeeJung; Ghosh, Moumita; Cravatt, Benjamin F.; Hsu, Ku-Lung; Bonventre, Joseph V.; Ewing, Heather; Gelb, Michael H.; Leslie, Christina C.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Mitochondrial calcium overload triggers permeability transition pore formation, fatty acid release, and necrotic cell death.

‣ Transglutaminase 2-dependent Deamidation of Glyceraldehyde-3-phosphate Dehydrogenase Promotes Trophoblastic Cell Fusion*

Iwai, Kaori; Shibukawa, Yukinao; Yamazaki, Natsuko; Wada, Yoshinao
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: This work explores proteins participating in trophoblastic cell fusion.

‣ Shear Stress-induced Redistribution of Vascular Endothelial-Protein-tyrosine Phosphatase (VE-PTP) in Endothelial Cells and Its Role in Cell Elongation*

Mantilidewi, Kemala Isnainiasih; Murata, Yoji; Mori, Munemasa; Otsubo, Chihiro; Kotani, Takenori; Kusakari, Shinya; Ohnishi, Hiroshi; Matozaki, Takashi
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Mechanical stimuli such as shear stress regulate endothelial cell (EC) function.

‣ Transcription of the SCL/TAL1 Interrupting Locus (Stil) Is Required for Cell Proliferation in Adult Zebrafish Retinas*

Sun, Lei; Li, Ping; Carr, Aprell L.; Gorsuch, Ryne; Yarka, Clare; Li, Jingling; Bartlett, Michael; Pfister, Delaney; Hyde, David R.; Li, Lei
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Stil is a human oncogene that is involved in cancer cell proliferation and survival.

‣ Endocytosis and Vacuolar Degradation of the Yeast Cell Surface Glucose Sensors Rgt2 and Snf3*

Roy, Adhiraj; Kim, Jeong-Ho
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: In yeast, glucose is sensed by two cell surface glucose sensors.

‣ A Novel Mechanism by Which Tissue Transglutaminase Activates Signaling Events That Promote Cell Survival

Boroughs, Lindsey K.; Antonyak, Marc A.; Cerione, Richard A.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Tissue transglutaminase (tTG) promotes various aspects of oncogenesis, including cell survival.

‣ Regulation of Induced Pluripotent Stem (iPS) Cell Induction by Wnt/β-Catenin Signaling*

Zhang, Peilin; Chang, Wen-Hsuan; Fong, Brendan; Gao, Fan; Liu, Chunming; Al Alam, Denise; Bellusci, Saverio; Lu, Wange
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Wnt signaling plays an important role in somatic cell reprogramming.

‣ Dicer Knockdown Inhibits Endothelial Cell Tumor Growth via MicroRNA 21a-3p Targeting of Nox-4*

Gordillo, Gayle M.; Biswas, Ayan; Khanna, Savita; Pan, Xueliang; Sinha, Mithun; Roy, Sashwati; Sen, Chandan K.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Endothelial cell tumors are the most common soft tissue tumor in infants.

‣ Hydroxycarbamide Decreases Sickle Reticulocyte Adhesion to Resting Endothelium by Inhibiting Endothelial Lutheran/Basal Cell Adhesion Molecule (Lu/BCAM) through Phosphodiesterase 4A Activation*

Chaar, Vicky; Laurance, Sandrine; Lapoumeroulie, Claudine; Cochet, Sylvie; De Grandis, Maria; Colin, Yves; Elion, Jacques; Le Van Kim, Caroline; El Nemer, Wassim
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Hydroxycarbamide treatment may inhibit the proadhesive features of vascular endothelium in sickle cell disease.

‣ βArrestin1 Regulates the Guanine Nucleotide Exchange Factor RasGRF2 Expression and the Small GTPase Rac-mediated Formation of Membrane Protrusion and Cell Motility*

Ma, Xiaojie; Espana-Serrano, Laura; Kim, Wan-ju; Thayele Purayil, Hamsa; Nie, Zhongzhen; Daaka, Yehia
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: G protein-coupled receptors (GPCRs) and βarrestins have been shown to regulate cell motility.

‣ Delay in Apoptosome Formation Attenuates Apoptosis in Mouse Embryonic Stem Cell Differentiation

Akbari-Birgani, Shiva; Hosseinkhani, Saman; Mollamohamadi, Sepideh; Baharvand, Hossein
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: The mitochondrial apoptotic pathway has a non-apoptotic role in cell differentiation.

‣ Binding of CD157 Protein to Fibronectin Regulates Cell Adhesion and Spreading*

Morone, Simona; Augeri, Stefania; Cuccioloni, Massimiliano; Mozzicafreddo, Matteo; Angeletti, Mauro; Lo Buono, Nicola; Giacomino, Alice; Ortolan, Erika; Funaro, Ada
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Surface CD157 modulates leukocyte and ovarian cancer cell adhesion and migration through the interaction with an unknown ligand.

‣ The Tetraspanin CD81 Protein Increases Melanoma Cell Motility by Up-regulating Metalloproteinase MT1-MMP Expression through the Pro-oncogenic Akt-dependent Sp1 Activation Signaling Pathways*

Hong, In-Kee; Byun, Hee-Jung; Lee, Jaeseob; Jin, Young-June; Wang, Sun-Ju; Jeoung, Doo-Il; Kim, Young-Myeong; Lee, Hansoo
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: CD81-associated tetraspanins influence the invasive and metastatic processes of various cancer cell types.

‣ Cell biology of fungal and oomycete infection of plants

Hardham, Adrienne R
Fonte: Springer Publicador: Springer
Tipo: Parte de Livro Formato: 40 pages
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In order to infect host plants, fungal and oomycete plant pathogens must overcome highly effective, constitutive physical and chemical barriers to pathogen ingress. They must avoid inducing additional host defences, and they must deploy mechanisms for obtaining from the plant the nutrients they need for growth and reproduction. Successful pathogens employ a range of infection strategies most of which include the key steps of adhesion to the plant surface, location of optimal penetration sites, penetration of the plant surface and acquisition of nutrients from the plant cells. Recent studies have greatly increased our understanding of the cellular and molecular mechanisms that underlie the infection process and we now have more information on the nature of pathogen adhesives, on the role of the cytoskeleton in hyphal growth and differentiation and on signalling molecules that regulate the development and function of a variety of specialised infection structures. Advances in technologies that allow broad scale gene discovery and determination of gene function are also bringing with them an explosion in our knowledge of genes and proteins involved in plant infection. In this chapter, these new data are reviewed in the context of our understanding of the cell biology of the infection process...

‣ How Taxol/paclitaxel kills cancer cells

Weaver, Beth A.
Fonte: The American Society for Cell Biology Publicador: The American Society for Cell Biology
Tipo: Artigo de Revista Científica
Publicado em 15/09/2014 Português
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Taxol (generic name paclitaxel) is a microtubule-stabilizing drug that is approved by the Food and Drug Administration for the treatment of ovarian, breast, and lung cancer, as well as Kaposi's sarcoma. It is used off-label to treat gastroesophageal, endometrial, cervical, prostate, and head and neck cancers, in addition to sarcoma, lymphoma, and leukemia. Paclitaxel has long been recognized to induce mitotic arrest, which leads to cell death in a subset of the arrested population. However, recent evidence demonstrates that intratumoral concentrations of paclitaxel are too low to cause mitotic arrest and result in multipolar divisions instead. It is hoped that this insight can now be used to develop a biomarker to identify the ∼50% of patients that will benefit from paclitaxel therapy. Here I discuss the history of paclitaxel and our recently evolved understanding of its mechanism of action.

‣ Optimal Ratio of Transcription Factors for Somatic Cell Reprogramming*

Nagamatsu, Go; Saito, Shigeru; Kosaka, Takeo; Takubo, Keiyo; Kinoshita, Taisuke; Oya, Mototsugu; Horimoto, Katsuhisa; Suda, Toshio
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: The somatic cell reprogramming factors do not always induce pluripotency.

‣ Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation

Qureshi, Omar S.; Kaur, Satdip; Hou, Tie Zheng; Jeffery, Louisa E.; Poulter, Natalie S.; Briggs, Zoe; Kenefeck, Rupert; Willox, Anna K.; Royle, Stephen J.; Rappoport, Joshua Z.; Sansom, David M.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: CTLA-4 is an essential regulator of T cell immune responses with unusual intracellular trafficking.

‣ RSK2 Protein Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration*

Gawecka, Joanna E.; Young-Robbins, Shirley S.; Sulzmaier, Florian J.; Caliva, Maisel J.; Heikkilä, Minna M.; Matter, Michelle L.; Ramos, Joe W.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: RSK2 alters cell migration and metastasis, but the mechanism is incompletely understood.

‣ Golgi Anti-apoptotic Proteins Are Highly Conserved Ion Channels That Affect Apoptosis and Cell Migration*

Carrara, Guia; Saraiva, Nuno; Parsons, Maddy; Byrne, Bernadette; Prole, David L.; Taylor, Colin W.; Smith, Geoffrey L.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: GAAPs regulate intracellular Ca2+ fluxes, cell migration, and apoptosis.

‣ Nicotine Induces the Up-regulation of the α7-Nicotinic Receptor (α7-nAChR) in Human Squamous Cell Lung Cancer Cells via the Sp1/GATA Protein Pathway*

Brown, Kathleen C.; Perry, Haley E.; Lau, Jamie K.; Jones, Dennie V.; Pulliam, Joseph F.; Thornhill, Brent A.; Crabtree, Clayton M.; Luo, Haitao; Chen, Yi. Charlie; Dasgupta, Piyali
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Nicotine promotes the proliferation of human squamous cell lung cancer (SCC-L) via the α7-nicotinic receptor (nAChR).