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‣ Axillary bud development in pineapple nodal segments correlates with changes on cell cycle gene expression, hormone level, and sucrose and glutamate contents
‣ Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta 1 integrin
‣ Ischemic preconditioning and the gene expression of enteric endothelial cell biology of rats submitted to intestinal ischemia and reperfusion
‣ Potential Molecular Mechanism for c-Src Kinase-mediated Regulation of Intestinal Cell Migration*S⃞
‣ Analogs of Tetrahydroisoquinoline Natural Products That Inhibit Cell Migration and Target Galectin-3 Outside of Its Carbohydrate-binding Site*
‣ Identification of a Novel Function of PiT1 Critical for Cell Proliferation and Independent of Its Phosphate Transport Activity*♦
‣ p110 CUX1 Homeodomain Protein Stimulates Cell Migration and Invasion in Part through a Regulatory Cascade Culminating in the Repression of E-cadherin and Occludin*
‣ Liganded Thyroid Hormone Receptor-α Enhances Proliferation of Pancreatic β-Cells
‣ Zyxin-mediated Actin Assembly Is Required for Efficient Wound Closure*
‣ A Novel Inhibitory Domain of Helicobacter pylori Protein CagA Reduces CagA Effects on Host Cell Biology*
‣ Synchronization of Cell Cycle of Saccharomyces cerevisiae by Using a Cell Chip Platform
‣ Human Folliculin Delays Cell Cycle Progression through Late S and G2/M-Phases: Effect of Phosphorylation and Tumor Associated Mutations
‣ Pax6- and Six3-Mediated Induction of Lens Cell Fate in Mouse and Human ES Cells
‣ A cell number-counting factor regulates group size in Dictyostelium discoideum
‣ Asymmetric cell division intersects with cell geometry : a method to extrapolate and quantify geometrical parameters of sensory organ precursors
‣ Pole Age Affects Cell Size and the Timing of Cell Division in Methylobacterium extorquens AM1▿†
‣ Index-sorting resolves heterogeneous murine hematopoietic stem cell populations
‣ The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function
Signaling from the G protein, Rap1 is involved in several fundamental biological processes. Yet the mechanism or even consequence of Rap1 signaling in several biologies and diseases is still unclear. Rap1 has been implicated in cancer tumorigenesis, but its role in cancer invasion and metastasis is less understood. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting that Rap1 may promote several processes associated with metastasis. Recent studies in another biological system have demonstrated that the Rap activator proteins, Epac, are important regulators of pancreatic β-cell insulin secretion. However, the role of Rap1 in β-cell biology has not yet been defined. Here we established roles for Rap1 in distinct signaling events and begin to answer some of the key questions about Rap1 function in two diverse biologies: cancer metastasis and pancreatic islet β-cell function.
Elucidating the mechanisms of prostate and breast cancer survival and metastasis are critical to the discovery of novel therapeutic targets. Examination of prostate cancer cell lines revealed cells with a high metastatic ability exhibited increased Rap1 activity and reduced expression of the negative regulator...