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- Biblioteca Digitais de Teses e Dissertações da USP
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‣ Análise da via de regulação gênica por ácido retinóico: uma abordagem por bioinformática e biologia estrutural; Analysis of retinoic acid pathway: an approach by bioinformatics and structural biology.
‣ Estudo comparativo da fotoxicidade das protoporfirinas IX endógena e sintética e seus fotoprodutos contra células malígnas; Comparative study of the phototoxicity of protoporphyrin IX, endogenous and synthetic and their photoproducts against malignant cells
‣ Immunolocalization of myosin Va in the developing nervous system of embryonic chicks
‣ Immunocalization of myosin Va in the developing nervous system of embryonic chicks
‣ A protein with protective properties against the cellular defense reactions in insects
‣ Evidence of high levels of methylglyoxal in cultured Chinese hamster ovary cells
‣ Dense Bodies of Human Cytomegalovirus Induce both Humoral and Cellular Immune Responses in the Absence of Viral Gene Expression
‣ Interaction of the Influenza Virus Nucleoprotein with the Cellular CRM1-Mediated Nuclear Export Pathway
‣ Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival
‣ In Vivo Accumulation of Cyclin A and Cellular Replication Factors in Autonomous Parvovirus Minute Virus of Mice-Associated Replication Bodies
‣ Cellular Effects of Reversed Amidines on Trypanosoma cruzi▿
‣ Markovianity of the invariant distribution of probabilistic cellular automata on the line
‣ Multi-Target Tracking with Time-Varying Clutter Rate and Detection Profile: Application to Time-lapse Cell Microscopy Sequences
‣ Scaling Laws and Topological Exponents in Voronoi Tessellations of Intermittent Point Distributions
‣ Assessing Random Dynamical Network Architectures for Nanoelectronics
‣ Construction of Reversible Lattice Molecular Automata
‣ Left-induced model structures and diagram categories
‣ Nano-biolistics: a method of biolistic transfection of cells and tissues using a gene gun with novel nanometer-sized projectiles
‣ Determination of cellular RNA concentrations by electron microscopy of R loop-containing DNA
‣ Multiple roles of epithelial signaling during craniofacial and foregut morphogenesis
Abstract
During embryonic development many structures crucial for breathing and eating arise from the pharyngeal and anterior foregut epithelium (FGE), which contains the oral ectoderm and the foregut endoderm. Proper differentiation and signaling within and from this epithelial tissue is necessary for the development of the mandible, the esophagus, and the trachea. Many birth defects occur in these structures that greatly disrupt the ability of affected infants to breathe and eat. This dissertation investigates the importance of the pharyngeal and anterior FGE in mandible and foregut development.
The most rostral portion of the pharyngeal epithelium contributes to the development of the mandible. At embryonic day 10.5 the mandible is a bud structure, composed of neural crest-derived mesenchyme and core mesoderm surrounded by pharyngeal epithelium. The mesenchyme needs to receive Hedgehog signaling for mandible development, but the epithelial tissue that signals to the mesenchyme has not been identified in mammals. Data presented in Chapter 2 show that Sonic Hedgehog is necessary at two distinct stages of mandible development by using a tissue specific genetic ablation to remove Sonic Hedgehog from the pharyngeal endoderm. First...