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‣ Modulation of Epithelial Morphology, Monolayer Permeability, and Cell Migration by Growth Arrest Specific 3/Peripheral Myelin Protein 22
‣ Teaching Cell and Molecular Biology for Gender Equity
‣ A Ramble through the Cell: How Can We Clear Such a Complicated Trail?
‣ Knockdown of ASIC1 and Epithelial Sodium Channel Subunits Inhibits Glioblastoma Whole Cell Current and Cell Migration*
‣ Gene Related to Anergy in Lymphocytes (GRAIL) Expression in CD4+ T Cells Impairs Actin Cytoskeletal Organization during T Cell/Antigen-presenting Cell Interactions*
‣ Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics
‣ Advancing Cell Biology Through Proteomics in Space and Time (PROSPECTS)*
‣ Integrating Quantitative Thinking into an Introductory Biology Course Improves Students’ Mathematical Reasoning in Biological Contexts
‣ Quantitative cell biology: the essential role of theory
‣ Quantitative biology: where modern biology meets physical sciences
‣ Spectral analysis of pair-correlation bandwidth: application to cell biology images
‣ miRNA-720 Controls Stem Cell Phenotype, Proliferation and Differentiation of Human Dental Pulp Cells
‣ Quantitative biology: where modern biology meets physical sciences
‣ 7.02 Introduction to Experimental Biology, Fall 2001; Introduction to Experimental Biology
‣ 7.012 Introduction to Biology, Fall 2001; Introduction to Biology
‣ 7.013 Introductory Biology, Spring 2005; Introductory Biology
‣ Video microscopy and digital image processing applied to tissue engineering: Intracellular ion and cell adhesion measurements
‣ Multi-step loading of human minichromosome maintenance proteins in live human cells; Running title: Maximal loading of MCM2/4 in late G1
‣ Explicit tracking of uncertainty increases the power of quantitative rule-of-thumb reasoning in cell biology
‣ Defining Roles for Cyclin Dependent Kinases and a Transcriptional Oscillator in the Organization of Cell-Cycle Events
The cell cycle is a series of ordered events that culminates in a single cell dividing into two daughter cells. These events must be properly coordinated to ensure the faithful passage of genetic material. How cell cycle events are carried out accurately remains a fundamental question in cell biology. In this dissertation, I investigate mechanisms orchestrating cell-cycle events in the yeast,
Cyclin dependent kinase (CDK) activity is thought to both form the fundamental cell-cycle oscillator and act as an effector of that oscillator, regulating cell-cycle events. By measuring transcript dynamics over time in cells lacking all CDK activity, I show that transcriptional oscillations are not dependent on CDK activity. This data indicates that CDKs do not form the underlying cell-cycle oscillator. I propose a model in which a transcription factor network rather than CDK activity forms the cell-cycle oscillator. In this model, CDKs are activated by the periodic transcription of cyclin genes and feedback on the network increasing the robustness of network oscillations in addition to regulating cell-cycle events.
I also investigate CDK-dependent and -independent mechanism regulating the duplication of the yeast centrosome...