Página 14 dos resultados de 45945 itens digitais encontrados em 0.050 segundos

‣ Small Efficient Cell-penetrating Peptides Derived from Scorpion Toxin Maurocalcine*

Poillot, Cathy; Bichraoui, Hicham; Tisseyre, Céline; Bahemberae, Eloi; Andreotti, Nicolas; Sabatier, Jean-Marc; Ronjat, Michel; De Waard, Michel
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: This study aimed at developing a new set of maurocalcine-derived cell-penetrating peptides from truncation.

‣ Redifferentiation of Expanded Human Pancreatic β-Cell-derived Cells by Inhibition of the NOTCH Pathway*

Bar, Yael; Russ, Holger A.; Sintov, Elad; Anker-Kitai, Leeat; Knoller, Sarah; Efrat, Shimon
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Human β-cell-derived (BCD) cells can be expanded in vitro in a process involving dedifferentiation and activation of the NOTCH pathway.

‣ Sialic Acid Associated with αvβ3 Integrin Mediates HIV-1 Tat Protein Interaction and Endothelial Cell Proangiogenic Activation*

Chiodelli, Paola; Urbinati, Chiara; Mitola, Stefania; Tanghetti, Elena; Rusnati, Marco
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: HIV-1 Tat engages αvβ3, leading to endothelial cell (EC) proangiogenic activation.

‣ Neural Transmembrane Protease and Endothelial Gs Protein Activation in Cell Contact-dependent Signaling between Neural Stem/Progenitor Cells and Brain Endothelial Cells*

Tung, Hsiu-Hui; Lee, Sheau-Ling
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Vasculature is a key component of the brain neurogenic stem cell niche.

‣ Protein Kinase Cα (PKCα) Regulates p53 Localization and Melanoma Cell Survival Downstream of Integrin αv in Three-dimensional Collagen and in Vivo*

Smith, Stephen D.; Enge, Martin; Bao, Wenjie; Thullberg, Minna; Costa, Tânia D. F.; Olofsson, Helene; Gashi, Behxhet; Selivanova, Galina; Strömblad, Staffan
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Integrin αv promotes melanoma cell survival in in vivo and in vitro three-dimensional environments.

‣ Fibrillar Structure and Charge Determine the Interaction of Polyglutamine Protein Aggregates with the Cell Surface*

Trevino, R. Sean; Lauckner, Jane E.; Sourigues, Yannick; Pearce, Margaret M.; Bousset, Luc; Melki, Ronald; Kopito, Ron R.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Polyglutamine aggregates can be internalized by mammalian cells and gain access to the cytoplasmic compartment, but the properties of the aggregates and cell surface that mediate these processes are unknown.

‣ Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays a Critical Role in β-Cell Survival under Endoplasmic Reticulum Stress: PROMOTING UBIQUITINATION AND DEGRADATION OF C/EBP HOMOLOGOUS PROTEIN (CHOP)*

Qi, Yanfei; Xia, Pu
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: How the adaptive ER stress response causes cell death remains enigmatic.

‣ Actopaxin (α-Parvin) Phosphorylation Is Required for Matrix Degradation and Cancer Cell Invasion*

Pignatelli, Jeanine; LaLonde, Sara E.; LaLonde, David P.; Clarke, Dominic; Turner, Christopher E.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: The process of matrix degradation is an integral component of cell invasion.

‣ Sumoylation Is Important for Stability, Subcellular Localization, and Transcriptional Activity of SALL4, an Essential Stem Cell Transcription Factor*

Yang, Feikun; Yao, Yixin; Jiang, Yongping; Lu, Luo; Ma, Yupo; Dai, Wei
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: SALL4 is a key stem cell transcription factor that transactivates OCT4.

‣ Epidermal Growth Factor (EGF) Regulates α5β1 Integrin Activation State in Human Cancer Cell Lines through the p90RSK-dependent Phosphorylation of Filamin A*

Vial, Daniel; McKeown-Longo, Paula J.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Regulation of integrin activation has important implications for tumor cell invasion and metastasis.

‣ Role of Molecular Determinants of Store-operated Ca2+ Entry (Orai1, Phospholipase A2 Group 6, and STIM1) in Focal Adhesion Formation and Cell Migration*

Schäfer, Claudia; Rymarczyk, Grzegorz; Ding, Lai; Kirber, Michael T.; Bolotina, Victoria M.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Store-operated Ca2+ entry is important for cell migration.

‣ Generation of a Drug-inducible Reporter System to Study Cell Reprogramming in Human Cells*

Ruiz, Sergio; Panopoulos, Athanasia D.; Montserrat, Nuria; Multon, Marie-Christine; Daury, Aurélie; Rocher, Corinne; Spanakis, Emmanuel; Batchelder, Erika M.; Orsini, Cécile; Deleuze, Jean-François; Izpisua Belmonte, Juan Carlos
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Strategies on the basis of doxycycline-inducible lentiviruses in mouse cells allowed the examination of mechanisms governing somatic cell reprogramming.

‣ Rad9 Protein Contributes to Prostate Tumor Progression by Promoting Cell Migration and Anoikis Resistance*

Broustas, Constantinos G.; Zhu, Aiping; Lieberman, Howard B.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Rad9, a cell cycle checkpoint and DNA repair protein, is functionally related to human prostate tumorigenesis.

‣ Rab26 Modulates the Cell Surface Transport of α2-Adrenergic Receptors from the Golgi*

Li, Chunman; Fan, Yi; Lan, Tien-Hung; Lambert, Nevin A.; Wu, Guangyu
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Mechanisms underlying the cell surface export of G protein-coupled receptors (GPCRs) are poorly understood.

‣ The Role of Microtubules and Their Dynamics in Cell Migration*

Ganguly, Anutosh; Yang, Hailing; Sharma, Ritu; Patel, Kamala D.; Cabral, Fernando
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Microtubule effects on cell migration are poorly understood.

‣ Dynamic Phosphorylation of Tyrosine 665 in Pseudopodium-enriched Atypical Kinase 1 (PEAK1) Is Essential for the Regulation of Cell Migration and Focal Adhesion Turnover*

Bristow, Jeanne M.; Reno, Theresa A.; Jo, Minji; Gonias, Steven L.; Klemke, Richard L.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Phosphoregulation of focal adhesion (FA) proteins regulates FA dynamics underlying cell migration.

‣ Neuregulin Mediates F-actin-driven Cell Migration through Inhibition of Protein Kinase D1 via Rac1 Protein*

Döppler, Heike; Bastea, Ligia I.; Eiseler, Tim; Storz, Peter
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: Neuregulin (NRG) is overexpressed in 30% of breast cancers and mediates tumor cell migration and invasion.

‣ ELMO Recruits Actin Cross-linking Family 7 (ACF7) at the Cell Membrane for Microtubule Capture and Stabilization of Cellular Protrusions*

Margaron, Yoran; Fradet, Nadine; Côté, Jean-François
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: ELMO and DOCK180 synergize to promote Rac-dependent cell migration.

‣ Mode of Cell Death Induction by Pharmacological Vacuolar H+-ATPase (V-ATPase) Inhibition*

von Schwarzenberg, Karin; Wiedmann, Romina M.; Oak, Prajakta; Schulz, Sabine; Zischka, Hans; Wanner, Gerhard; Efferth, Thomas; Trauner, Dirk; Vollmar, Angelika M.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: V-ATPase is proposed as tumor target, but information on cell death-inducing mechanisms is rare.

‣ Cdk1 Protein-mediated Phosphorylation of Receptor-associated Protein 80 (RAP80) Serine 677 Modulates DNA Damage-induced G2/M Checkpoint and Cell Survival*

Cho, Hyun Jung; Oh, Yun Jung; Han, Seung Hun; Chung, Hee Jin; Kim, Chang Hee; Lee, Nam Soo; Kim, Won-Ju; Choi, Je-Min; Kim, Hongtae
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
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Background: RAP80, a component of the BRCA1-A complex, is crucial in the cell cycle checkpoint and DNA damage repair.